Possible protective role of probiotic and symbiotic to limit the progression of chronic kidney disease in 5/6th nephrectomized albino rats

Abstract Background The unbalanced gut microbiota, poorly ingested enriched fiber foods, leaky is connected to the progression of chronic kidney disease (CKD). translocates uremic toxins systemic circulation, promote inflammation, worsen CKD. Decreasing influx from may decrease So, we aimed evaluate effect probiotic and symbiotic supplementation on their role prevent CKD progression. Methods 48 white albino rats were randomly allocated into 6 groups: sham group; rats; treated rats. Treatment started either immediately or 2 weeks after operation for each group. Blood pressure, body weight changes, serum level urea, creatinine, indoxyl sulphate CRP determined. Histological studies remnants intestine renal fibrosis index calculated. SPSS program was used statistics. Results Serum sulphate, CRP, blood pressure significantly increased in Probiotic treatment decreased creatinine index. Symbiotic compared upon treatment. Conclusions A strong correlation between microbial ecosystem has been proved. use probiotics modulate an unhealthy microbiome a promising intervention delay specially early stages. results better than alone.